Tuesday, March 6, 2007

Avian Influenza


What is Avian Influenza / Bird Flu?

Ghanadi.A - Sadeghi.H - Rahmani.M
Pharmaceutical Research Center, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, I.R. Iran

An infection caused by influenza viruses that occurs naturally in birds. Wild birds can carry the viruses, but usually do not get sick. Some domesticated birds can become infected, usually fatally . Strains of avian flu may infect other types of animals, incl. pigs, cats and tigers . In this article reveiw we discuss about following related drugs.

1-Neuraminidase cleaves terminal sialic acid residues from carbohydrate moieties on the surfaces of infected cells.

2-Oseltamivir is an antiviral drug that is used in the treatment and prophylaxis of both Influenzavirus A and Influenzavirus B. It is a neuraminidase inhibitor

3-Shikimic acid derivatives , shikmic acid byself is an important biochemical intermediate in plants and microorganisms
Such as the aromatic amino acids phenylalanine and tyrosine , indole, indole derivatives and tryptophan , many alkaloids and other aromatic metabolites , tannins, flavonoids, and lignins.

4-Quinic acid , C7H12O6 is a crystalline acid obtained from cinchona bark, coffee beans, and other plant products and made synthetically by hydrolysis of chlorogenic acid

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