Saturday, April 28, 2007

TAXOL PRODUCTION AND PLANT BIOTECHNOLOGY


Sh. Dehshahri , G. Asghari

Pharmaceutical Research Center, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, I.R. Iran

In recent years have seen great achievements in the production of taxoids using cell cultures.
for example paclitaxel production yield improvement: from about 1mg/l to more than 100mg/l.

in 1994, Phyton and ESCA genetic conducted taxus suspension cultures in 75,000-l and 2500-l bioreactors respectively. In 2001, the commercial production of paclitaxel using plant cell suspension cultures was achieved by Samyang Genex.

This successful industrial application of a plant cell culture will trigger future research on the production of plant-derived beneficial compounds.


What is taxol?
paclitaxel (TaxolTM ) is a diterpenoid alkaloid originally isolated from the bark of pacific yew, Taxus brevifolia .
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